All three goals came in a frantic opening 20 minutes on Tyneside with Vertonghen and Alli heading goals for the north London team, who finished third last season, on either side of an 11th minute equaliser by Joselu.
"I am not going to complain and we have to learn to be clever".
However, any concerns about a lack of fresh faces were quickly alleviated in an end-to-end opening at a sun-kissed St James' Park.
In the event, Vertonghen's contribution did not prove decisive at St James' Park as Joselu levelled within three minutes, and it took Dele Alli's 18th-minute back-post header to win it in a lively start on Tyneside.
On how people interpreted his comments at the end of last season, Pochettino added: "I am responsible for what I told you or what I tell you but I can not be responsible for what you believe that I wanted to tell you".
Substitute Rondon nearly snatched a point five minutes from time when his shot hit Vertonghen and looped over Lloris, only for the ball to come back off the crossbar. "I was so happy about that".
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"It's a great challenge for us to shut everyone up, really", he said.
But they showed enough against one of the league's top sides to suggest they should be competitive again this season.
Nevertheless, this latest dramatic development comes as no surprise to sources working on the rebuild, who had long predicted that a return to playing home games at the start of this season was always overly ambitious given the extent of the work.
An NFL fixture between Seattle Seahawks and Oakland Raiders, scheduled to be hosted on 14 October, will also now take place at Wembley instead of Spurs' new 62,062-seat arena, built on the site of their old White Hart Lane ground. Tottenham regained the lead in the 18th minute from another header, this one by Dele Alli, found at the back post by Serge Aurier's cross.
Diame was afforded room in the box to clatter a left-footed shot against the upright, while Alli should have done better at the other end when picked out by another delightful Eriksen ball. "The manager said it before - we're in a fight but we're having to use different tools".
"You could feel fans had the belief we could do something".
"We deserved more. The team worked hard".