Bernardo Silva started and scored in the win against Arsenal and the Portugal worldwide could remain a starter in De Bruyne's absence.
De Bruyne arrived on crutches on Wednesday evening at the premiere in Manchester of Amazon's "All or Nothing" documentary about the club.
"We don't just rely on one player. Obviously it's a big loss but we've got more than enough cover".
Third night of anti-government protests in Romania
There was some violence: protesters tried to break through a security line while others threw bottles and rocks, reported Reuters. Over 400 people received medical care at the square that night and two gendarmes were attacked, it said.
"He had so much impact on our game".
Due to being given three weeks off following the World Cup he did not play a role in the Community Shield win against Chelsea but came on for a cameo role of half an hour in the 2-0 opening Premier League victory over Arsenal last Sunday.
De Bruyne, 27, is expected to fly to Barcelona for further tests with specialist Dr. Ramon Cugat who treated him when suffered a knee injury in January 2016.
If the current injury proves to be as serious, De Bruyne would miss the start of City's Champions League campaign and a potentially important Premier League clash at Liverpool on 7 October.
Punters were also quick to scoop up the huge prices available on Huddersfield to shock the champions at the Etihad on Saturday.