The Chiefs, as they have all season, jumped out early and put on an outstanding offensive display, and the 49ers really couldn't keep up. He pulled up, suffering a non-contact knee injury before taking a hit from the Chiefs defense.
Stay tuned for further updates. Their only other quarterback now on the team is second-year player Nick Mullens, who's on the practice squad.
For the third week in a row Mahomes has proven what I said all along: Brett Favre is not a good comparison for him. "I knew that from the day we met, when we got drafted together".
If Garoppolo is unable to play next week against the Chargers, C.J. Beathard would likely start as quarterback, unless the 49ers front office decides to explore a trade or free agency.
Top cornerback Richard Sherman went down with a calf injury, while backup Tarvarius Moore left with a wrist injury.
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Beathard threw what appeared to be a 7-yard touchdown pass to Kittle on a fourth-and-goal play. And Beathard will be expected to play at a high level and give the 49ers a chance to win, according to his coaches and teammates.
The 49ers have only kept two quarterbacks on the 53-man roster since Shanahan became coach.
The 49ers were still trailing 38-24 when Garoppolo led them inside the Kansas City 5 in the final minutes.
Garoppolo started the 49ers' first three games, throwing for 718 yards and five touchdowns this season.
That's when the San Francisco quarterback headed for the sideline, made a decision to stay in play rather step out of bounds, and ultimately put the rest of the 49ers' season in question.
If you think we're getting too carried away with the Mahomes love, he did miss two touchdowns in the first half Sunday - a would-be 49-yarder that was underthrown to Tyreek Hill and a would-be 61-yarder on which he overshot Harris.