The ad reads, "Believe in something, even if it means sacrificing everything".
Nike's stock price fell by almost 4% when Kaepernick first revealed he was fronting the campaign on social media. Vice President Mike Pence walked out of an Indianapolis Colts game after some players knelt.
Kaepernick is only shown twice in the ad, once in the middle and in the closing seconds.
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The Fraternal Order of Police also criticized Nike for the ad campaign.
It also enraged his supporters who posted videos and pictures of themselves torching their Nike merchandise on social media, where the subject was trending. "If Nike is ashamed of America, we are ashamed of them".
"Since 2016, 381 officers have been killed in the line of duty", the order's president, Chuck Canterbury, said in a statement, "They believed in something and sacrificed everything, as did the families they left behind. Only time will tell".
Kaepernick finishes the ad by saying: "Don't ask if your dreams are insane".
Over a photo of a Nike T-shirt cut into pieces, McGaugh Elementary School Principal Roni Burns-Ellis wrote on her personal Facebook page: "My newest rag!" They really use their platform in ways that is really unfathomable... "You can't do nothing but respect them".
News 3's Emily Manley reached out to multiple resale shops in the area, asking if they have seen an increase in Nike donations.