England got their UEFA Nation's League campaign off to a losing start on Saturday, with the Three Lions losing 2-1 to Spain in their first competitive defeat at Wembley since a Euro 2008 qualifier against Croatia in November 2007.
Having got the assist to put England 1-0 up in the first half, Shaw's return to worldwide football had started brilliantly.
Before the game, England coach Gareth Southgate had warned that his team still had much to prove on the global stage, claiming that the country's winning record against world football's elite has been "non-existent" since the World Cup success in 1966.
"Winning like this on this stage will do us a lot of good and we've started in the best way possible but in football the only thing that matters is the present". We can either go back to our old style and we'll never be a top team, or we can keep trying to do what we do and suffer at times.
Rashford was also replaced in added time by Danny Welbeck, after signalling to the bench that he had picked up a knock.
Medics rushed onto the pitch to give Shaw, 23, oxygen and carry him off on a stretcher.
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Kane said he was happy with England's performance, despite a third consecutive defeat dating back to the World Cup semi-finals.
"I have seen teams fold in that sort of situation but we finished really strongly, created a couple of very good chances", Southgate said.
And though backed by a packed-out Wembley and the tiresome England Band, Southgate's side were unable to restore parity.
"But I'm proud of the way we finished the game".
Harry Kane released Shaw down the left and the full-back picked out his Manchester United team-mate Rashford with a precision pass that was slotted past David de Gea in the 11th minute. During the World Cup she posed in the Spain goalkeeper's kit and makes a point of congratulating him whenever possible.
"We have to expect that Spain were better than us for long periods of the game", Southgate said.