Cory Martino says the pilot died as well as four occupants of the home in Yorba Linda, which is about 35 miles (56 kilometers) southeast of Los Angeles.
The Cessna 414A had just departed the Fullerton Municipal Airport.
The Federal Aviation Administration said the twin-engine Cessna 414A crashed in Yorba Linda shortly after taking off from the Fullerton Municipal Airport Sunday afternoon.
The Orange County Fire Authority said crews were responding to two homes.
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The FAA and the National Transportation Safety Board are investigating the incident, Kenitzer told KTLA.
Seventy-two fire fighters attended the scene alongside local police, with the investigation into the crash still ongoing.
A two-story house burst into flames after being struck by the main cabin and one engine of the plane, sending panicked neighbours into the streets. The two who suffered injuries were transported to a local hospital, authorities said. Other homes were damaged by debris from the plane, which crashed in the backyard of another home.
The number of people in the plane are unknown. "It shook our house".
Video posted on Twitter showed panicked residents running to the house as it became engulfed in flames and dark smoke. It was unclear if they were in the house or the plane.