Despite an initial assumption Icardi had been dropped, coach Luciano Spalletti later clarified that the Argentina global withdrew from the squad himself, although the Nerazzurri boss did not offer a reason.
"The decision to take the captain's armband off Icardi was hard and painful because we know all about his value", Spalletti said at a news conference.
"But it was divided between all parts of the club and was made exclusively for the good of Inter".
"Obviously he was disappointed, but there are things going on which are disturbing him and the team".
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It is understood that the decision was a mutual one between the Serie A club and manager Luciano Spalletti.
The Argentine striker who is on a seven-game goal-dought has reportedly been at loggerheads with the club's hierarchy over a new contract, amidst interest from Europe's elite.
"I have not created any problems for Icardi", Spalletti told DAZN.
Icardi is reported to have a €110-million release clause in his current contract, valid only for bids from clubs outside of Italy.
The Slovenia global, 34, joined Inter from Udinese in 2012 while Icardi arrived from Sampdoria in 2013, taking over as captain from Andrea Ranocchia in 2015.
Since then he has scored 122 goals in 210 appearances for the Nerazzurri, including 15 goals in 28 appearances in all competitions this season.