"Either you know or be [quiet]", she said.
"We've seen how that ends", Clooney continued.
Prince Harry, Duke of Sussex and Meghan, Duchess of Sussex attend a gala performance of "The Wider Earth" in support of the Queen's Commonwealth Trust & the Queen's Commonwealth Canopy at the Natural History Museum on February 12, 2019, in London, England.
In a nutshell, she employed the KonMarkle Method, a strategy that's all about removing (or ignoring) anyone around you who's not "sparking joy".
Clooney, who attended Meghan and Harry's wedding past year alongside his wife, human rights lawyer Amal Clooney, said he had seen the recent coverage about the Duchess's supposed letter.
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The Duchess of York, who was married to Prince Andrew for a decade before the pair went their separate ways in 1996, then reflected on the way her relationship with Princess Diana had been portrayed. "She's getting a raw deal there, it's irresponsible".
In the deeply personal missive, Meghan accuses her father of breaking her heart "into a million pieces" by giving interviews to the press, fabricating stories and attacking her new husband.
The Duchess of Sussex said she had tried to get in contact with her father by calling, texting and even sending someone to his house. "We've been told that numerous times by people that know that that was the case".
Kensington Palace has not yet responded to CNN's request for comment.
It's claimed Samantha - an outspoken critic of the Duchess - will appear in two TV documentaries, chat shows, a book and $2,600-an-hour interviews to talk about her niece or nephew and relationship with Meghan.