A Romelu Lukaku double and a first Premier League goal for Andreas Pereira were enough to cancel out goals from Jan Valery and James Ward-Prowse and help United secure all three points; closing the gap on Tottenham in third place to just three points.
The Saints shocked Old Trafford when they took the lead when young French full-back Yan Valery scored a scorching goal in the 26th minute.
"I'm just not sure you are ever going to win the league with a goalscorer like him", said former United midfielder Paul Scholes in November, towards the end of Lukaku's 12-game goal drought in all competitions. "I have been part of it so many times myself".
The Portuguese coach has been a special guest of beIN SPORTS this weekend, taking in El Clasico and was quick to react when asked about his relationship with players whilst at Manchester United.
There have been news that Ole Gunnar Solskjaer is planning to make Pogba the next captain as Antonio Valencia is on the verge of leaving the Old Trafford club.
"We spoke at half-time: get more urgency, get the ball in the box, and the strength of them [the fans] will suck the ball in".
"We should have been two up in the first five minutes".
Thousands gather at border to welcome back Indian pilot
It said other airports, including one located in the eastern city of Lahore that borders India, will remain closed until March 4. Pakistani officials handed over Varthaman to Indian officials, including from the IAF , at the Attari-Wagah Border late Friday.
And United were ahead just before the hour mark when Lukaku slotted an effort into the bottom corner, having been played in by Pereira.
The 25-year-old has been integral to the club's climb to fourth in the Premier League, although he fluffed the chance to get on the scoresheet against Southampton when Angus Gunn saved his stoppage-time penalty.
"We know it is going to be a tough game, but who knows?"
"Rom is a goalscorer, he keeps practising every single day and has quality".
"A lot of very good decisions we made in the first half and in the second half we were not scared if they put more pressure on us but we had a few crucial things".
Next up for Spurs is a trip to Borussia Dortmund for the second leg of their Champions League last-16 tie on Tuesday.
We were not far away from it and also after the 2-1 we did not stop attacking them and creating for us.
"We came back and then one fantastic player decided this game with his unbelievable power and that's the end".