It would be a 28th trophy in four countries for the five-time Ballon d'Or victor, a haul which includes five Champions League, and the Euro 2016 title with Portugal.
Midfielder Arturo Vidal, who did start the game, said Barca's players had been distracted by Tuesday's game against United. "If we get to injury-time we are a fit team".
"I don't know what Manchester United are going to do but we do have the references of what they've been doing in the Champions League this year", Valverde added.
On that occasion it came before a Champions League second leg against Atletico Madrid at the Estadio Vicente Calderon, when the Catalans had a 2-1 first-leg advantage. After an impressive win against Manchester United in an away tie, they will switch their focus on the league which is nearly done and dusted.
"We will make changes but with the aim of putting out a competitive team".
"We want to go out and dominate from the start but, when we have to defend, we have to defend like we did at Old Trafford".
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Juventus beat SPAL 2-0 in November.
Juventus boss Massimiliano Allegri made nine changes to his starting line-up from the side which faced Ajax in the Champions League in midweek, with debutants Grigoris Kastanos and Paolo Gozzi among the starters.
"We respect what they have done, what they are and the history they have behind them".
Their fortunes have improved a little since Leo Franco was replaced by Francisco in October, after he'd won only once at a points-per-game average of 0.625 in the opening eight matches of the season.
Overall, they were better than Huesca but never really got out of second gear.
It took the Englishman just 30 minutes to wipe out Barca's star man on Wednesday night, crashing through the back of him to win the ball.
"There is pride and confidence, but if we do not win we are stuffed".