Microsoft planned to integrate Paint's features into the Paint 3D app. Microsoft says that users who try to install the update now might face "inappropriate drive reassignment" if USB storage devices or SD card readers are connected during Setup leading to reassignment of different drive letters. To get around it, remove any external USB or SD cards and restart your update installation.
Most of the main MS Paint functions were to be integrated into the more modern Paint Microsoft still remains committed to Paint 3D, or why there will continue to be two paint apps included with Windows 10 in the future. This isn't the first wonky thing to happen to Windows 10 updates, but it still seems quite annoying.
So you can understand why Microsoft has blocked upgrades in the case of computers with such USB devices attached. For this reason, these computers are now blocked from receiving the May 2019 Update.
The workaround is fairly straightforward: unplug any USB drives or other devices, and take out any SD cards. The operating system giant also informed that it is too early to determine the fate of Sets. Slightly ominously, though, that still might not leave you entirely safe from the May 2019 Update error.
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On top of all that, there's a little note at the bottom of the document that states "The drive reassignment is not limited to removable drives".
Example: An upgrade to the May 2019 Update is tried on a computer that has the October 2018 update installed and also has a thumb drive inserted into a USB port.
The good news is that Microsoft is working on a fix.
In the event that a user does not see an announcement or coverage (such as what you are reading right now) about this, they will be able to update in the future when Microsoft rolls out a future update to resolve this.