However, Guardiola, whose side face Rose's Tottenham in the first leg of their Champions League quarter-final tie next week, encouraged the left-back to stand up and continue the fight against discrimination.
"The coach wants to win every game and every cup, and to put young guys in... the task is sometimes very hard for a manager".
One of those, Sergio Aguero, will be assessed on Saturday morning to determine whether he is fit enough.
However against Cardiff we were expecting a tentative half speed De Bruyne but what we got was something much more akin to the past.
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The women have said that his attempts to make physical contact and show affection made them uncomfortable and were inappropriate. Another source who has been in contact with Biden's team said the flap over his personal conduct had been anticipated.
"I think you can look at any position, all across their team and subs - and probably the players who don't even make the 18 - majority could walk into a lot of clubs across European football", he said.
Stand-in left back Oleksandr Zinchenko has a hamstring injury and Guardiola is ready to draft Benjamin Mendy, who has been recovering from a knee injury, into the side for the first time January 23 as a result. "I've been injured and have had to come back three or four times now".
Another is Kevin De Bruyne, whose performances have gone up a few notches over the past week and towards the end of a frustrating campaign. Now it's the business end and I just need to do what I can to help the team win games. Brighton are a side committed to playing attractive football and I'm really looking forward to facing them at this handsome stadium. Tottenham last title was against Chelsea in the League Cup in 2008, Spurs defeated Chelsea 2-1 to win the title at the Wembley Stadium. You can not achieve important titles without important players saying: 'Guys, I'm here.' Fortunately the managers don't play - it's a moment for the players'. You see the amount of changes we made [against Cardiff on Wednesday].
"The occasion, the stadium, it's what you dreamt about as a young boy and hopefully we can get the job done".
"To play here, in any top team in England, where you have 20 star players who are all top internationals who have played five to 10 years for their countries and for big teams, and have the minutes he has, is incredible".