Ronaldo's impressive goalscoring record in the Champions League continued as his header, which was directed in after Joao Cancelo's accurate cross, was his competition-leading 125th.
Messi was left with a swollen eye and a bloody nose after being caught in the face by Smalling's elbow during the first leg of their Champions League quarter-final.
The five-time Ballon d'Or victor was left battered and bruised after a harsh challenge from Smalling just past the half-hour mark in United's first-leg quarter-final 1-0 loss to the Blaugrana on Wednesday.
Ronaldo has scored a truly ridiculous amount of goals in the latter stages of the competition.
However, David Neres curled home for the hosts at the beginning of the second period to leave the quarterfinal tie delicately poised at 1-1.
"Ronaldo proved once again he is a player of a different level", Juventus coach Massimiliano Allegri said after the match.
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But, he added, "While it failed to land successfully, overall it was a path-breaking and innovative project". But Beresheet was not a science mission at heart. "It just takes one little glitch", he said.
Ronaldo was returning from a two-week injury layoff.
The Serie A champions-in-waiting will still be favourites to go through to the semi-finals, especially with the second-leg being in Turin. "I thought it would be four as something similar happened with [Gerard] Pique and he missed four games".
"He started the action and he wrapped it up [with the goal]".
"Barcelona was not Barcelona yesterday, I think United had one player that was responsible for that because I think Scott McTominay in midfield he was like what I used to call - but when I use this expression it's obviously in the total positive sense of the word". Bernardo Silva was ruled out ahead of the match, but Pep Guardiola's comments after the game suggest the Portugal man was not seriously injured.
"The Emperor is back", wrote Corriere dello Sport as Ronaldo played for the first time since his hat-trick against Atletico Madrid sealed Juventus's comeback and quarter-final berth. "During the season there are injuries, there are problems and hopefully next week maybe Bernardo will be fit".