Projections for the results of the European Elections have suggested that Nigel Farage's Brexit Party will receive the most seats of any party in the United Kingdom, with Lib Dems in second and Labour in third.
Farage began celebrating as the first exit polls started coming in.
"It looks like it's going to be a big win for the Brexit Party", Farage told reporters in Southampton in southern England where he is running.
The Remain vote appeared to be split between several parties, with The Liberal Democrats, The Green Party, Change UK and Labour all potentially picking up voters who want to remain in the EU.
The Brexit Party did particularly well in Thanet in Kent, taking nearly half of the vote (49%).
He said that it had become the leading Remain party, had picked up votes from both Labour and the Conservatives and was "back in business".
Theresa May's resignation couldn't please the GBP buyers for long as disappointments from Brexit Party's lead are on the rise. The Tories saw their voter support sliding due to the Brexit deal debacle that precipitated the PM's long-awaited bow-out.
"Results are likely to make for very anxious people in CCHQ (Conservative campaign HQ) and Labour HQ about how many seats we could pick up in a general (election)", the source said.
Britain is participating in the EU election because it is still a member of the bloc, but the lawmakers it elects will only sit in the European Parliament until the country leaves the EU, which is now scheduled for October 31.
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Labour came third in Wales - where it has only once before failed to win (in the 2009 European election).
Results from across the region were last night being collated in Birmingham before the seven West Midlands seats were distributed to reflect the vote.
The European Parliament's Brexit co-ordinator said the Liberal Democrats result of 15 seats was "amazing".
The favorites, including ex-Brexit Secretary Dominic Raab and former Foreign Secretary Boris Johnson, have vowed to leave the European Union on October 31 even if there is no deal in place.
The remaining results, in Northern Ireland and Scotland, won't be announced until later on Monday.
Green leaders in the European Parliament are hailing a "green wave" that has spread throughout Europe after early projections showed the environmentalist movement was likely to make significant gains.
A European Parliament official estimated a turnout of 51 per cent for 27 of the 28 EU states - all except the UK.