Corruption watchdog National Accountability Bureau had issued arrest warrant on him on Sunday.
Meanwhile, Interior Minister Ijaz Ahmed Shah said the Islamabad High Court has rejected bail plea of former President Asif Ali Zardari and the government has nothing to do with it.
The cases against Zardari are part of the investigations being conducted by NAB in pursuance of the Supreme Court's verdict in the money laundering of billions through fake accounts case.
Zardari, now a lawmaker in Parliament, and his sister Faryal Talpur, also a politician, are accused of having dozens of bogus bank accounts.
Former Pakistan president and Pakistan People's Party (PPP) co-chairman Asif Ali Zardari has reportedly been arrested.
The two attended the court hearing but were not arrested at the scene. All the roads leading to Zardari House have been sealed off.
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Zardari, now a lawmaker in the lower house of Parliament, and his sister, also a politician, have been accused of having dozens of bogus bank accounts.
Small scuffles erupted between police and supporters of Zardari's Pakistan People's party (PPP) outside his family's residence in Islamabad as he was taken into custody.
On the other side, Asif Zardari and Bilawal Bhutto Zardari have started consultations with their legal team, sources said.
Asif Ali Zardari will now be transferred to NAB office in Rawalpindi.
Party workers staged protests across the country, mainly in Nawabshah, Larkana, Sukkur, Lahore, Hyderabad and Karachi.
He also requested for a issuing production order for former railways minister Khawaja Saad Rafique.